Formulation Development

Overview

Althea's Crystalomics® technology allows proteins and other large molecule products to be formulated as crystals. These formulations allow manufacturers to overcome stability and delivery challenges with products that need to be delivered at high concentrations or must be administered frequently. Crystalomics® offers a better solution for these challenging applications.

Protein Formulation Technology - Crystalomics®

High Concentration Formulations

  • Suspension formulations of mAB’s have the potential of delivering higher doses in a smaller injection volume
  • Potential for concentrations >200mg/ml

Sustained Release Formulations

  • Extended release of a week or longer
  • Good injectability with a low initial burst

 

Crystalomics™

Integrated
Value

case-inner-biologics-manufacturing

Biologics Manufacturing

Every biologic requires a stable formulation prior to downstream manufacturing.  Every biologic needs a custom formulation after purification to ensure stable API.  Formulations at Althea can be readily applied in our cGMP facility, rather than transferring the process to another service provider.  Learn More

Protein Analytics /
Stability Testing

With protein analytics tied to the formulations group, you can be sure that every piece of analytical capability is there to support your formulation without the need to ship samples to a third party. 
Learn More

case-inner-protein-analytics

Aseptic Fill & Finish

Forget about shipping your valuable API from facility to facility for each step of the manufacturing program.  Once your API has been formulated, it can be readily filled into vials or syringes for clinical or commercial use.  This means less product transfer, less cost, less time.  Learn More

case-inner-aseptic-fill-finish